中国临床药理学与治疗学2011，Vol.16Issue(4)：439-446,8.
代谢组学在代谢性疾病研究中的进展
Progress of metabonomic study on various metabolic diseases
摘要
Abstract
Changes of modern living style and food structure greatly challenge biochemical metabolism of our body. Consequently, there appears an increasing rate of the metabolic diseases, such as hypertension, diabetes, dyslipidemia, tumor and so on, which do seriously harm to public health. Although substantial evidences have proved that metabolic diseases are tight associated with metabolic disorders, the underlying pathogenic mechanism is poorly known. By quantitative measuring of the in vivo molecules, metabonomics enables a dynamic profile of metabolic response of living systems to pathologic, genetic and environmental stimuli,and provides metabolic data for further exploring these diseases. Recently metabonomic studies have gained fruitful achievements, which show that in vivo biochemical metabolism is perturbed during the development of these diseases, including energy metabolism, lipids metabolism and amino acids turn over. Additionally, metabololism of fatty acids are possible to build the interchangeable association among hypertension,diabetes, and dyslipidemia,both oxidative stress and insulin resistance are deeply involved in their linkage. This article reviews recent studies of metabonomics on the metabolic diseases, aiming at clarifying the association between metabolic diseases and metabolic disorders, and providing potential strategy for the prevention and management of metabolic diseases.关键词
代谢组学/高血压/脂质紊乱/糖尿病/肿瘤/基础代谢Key words
Metabonomics/ Hypertension/Dyslipidemia/ Diabetes mellitus/ Tumor/cancer/Metabolism分类
医药卫生引用本文复制引用
赵春艳,阿基业,曹蓓,刘林生,王新文,李梦婕,石建,王广基..代谢组学在代谢性疾病研究中的进展[J].中国临床药理学与治疗学,2011,16(4):439-446,8.基金项目
"十一五"国家重大新药创新专项平台项目(2009ZX09304-001)、"十一五"国家重大新药创新技术项目(2009ZX09502-004) （2009ZX09304-001）
国家重大基础"973"研究项目(2011CB505300＆2011CB505303) （2011CB505300＆2011CB505303）
国家自然科学基金项目(81072692) （81072692）
