中国临床药理学与治疗学2011，Vol.16Issue(4)：455-460,6.
基因多态性对氨氯地平药代、药效的影响
Effects of polymorphic gene on the pharmacokinetics and pharmacodynamics of amlodipine
摘要
Abstract
Amlodipine, 1,4-Dihydropyridine calcium channel antagonists, prescribed in the management of angina and hypertension, act as substrates of CYP3A5, has a pharmacokinetic profile that differs from other dihydropyridines.It has been suggested that the CYP3A5* 3 allele contributes to the interindividual variability of CYP3A activity in vivo. This review aimed to summarize the clinical application of the amlodipine and the possible role of the genetic polymorphism CYP3A5 on the pharmacokinetics and pharmacodynamics of amlodipine and instruct the reasonable clinical application of amlodipine.关键词
CYP3A5/氨氯地平/药动学/药效学Key words
CYP3A5/ Amlodipine/ Pharmacokinetics/ Pharmacodynamics分类
医药卫生引用本文复制引用
杨夏玲,杨婧芝,熊玉卿..基因多态性对氨氯地平药代、药效的影响[J].中国临床药理学与治疗学,2011,16(4):455-460,6.基金项目
国家"十一五"科技重大专项"建立新药研发安全监测信息化技术平台"子课题"构建期临床试验研究和风险监测的信息化监管技术平台"(2009ZX09309-003-02) （2009ZX09309-003-02）
