生物骨科材料与临床研究2011，Vol.8Issue(3)：1-4,4.DOI:10.3969/j.issn.1672-5972.2011.03.001
纳米羟基磷灰石/Ⅰ型胶原/壳聚糖复合支架材料的制备与优化
Fabrication and Optional Design of Nano-Hydroxyapatite /Collagen Ⅰ/Chitosan composite Scaffolds for Bone Tissue Engineering
章文苑 1律娅婧1
作者信息
- 1. 西华大学物理与化学学院,四川,成都,610039
- 折叠
摘要
Abstract
Objective A novel nano-hydroxyapatite/type Ⅰ collagen/chitosan(nano-HA/COL/CS) scaffolds was fabricated for bone tissue engineering. Methods An in situ synthesis method was applied in fabricating the scaffolds in stead of mixing HA powder with COL/CS solution, and then a freeze-drying method was used to fabricate porous scaffolds for bone tissue engineering. Results It was easier to get a homogeneous mixture of two solution systems than of solid powder and solution. The better surface energy of apatite leads a better stability of the scaffold. Conclusion Then scaffolds were irradiated by UV to enhance the mechanical strength. The scaffold we prepared could meet the needs of bone tissue engineering with its enhanced mechanical strength.关键词
骨组织工程/纳米羟基磷灰石/Ⅰ型胶原/原位合成Key words
Bone tissue engineering/ Hydroxyapatite/ Type Ⅰ collagen/ In situ synthesis分类
医药卫生引用本文复制引用
章文苑,律娅婧..纳米羟基磷灰石/Ⅰ型胶原/壳聚糖复合支架材料的制备与优化[J].生物骨科材料与临床研究,2011,8(3):1-4,4.
