中国临床药理学与治疗学2011，Vol.16Issue(4)：407-411,5.
加味逍遥丸对CYP2C19酶活性的影响
Effect of Modified Xiaoyao pill on the activity of CYP2C19
赵钢涛 1杨凡 1许茜 1丁媛媛 1郑绯 2许景峰1
作者信息
- 1. 北京军区总医院药理科,北京100700
- 2. 中国人民解放军第302医院药学部,北京100024
- 折叠
摘要
Abstract
AIM: To investigate the effect of Modified Xiaoyao pill on CYP2C19, and provide foundation for clinical drug using. METHODS: Twenty volunteers were divided into two groups according to CYP2C19* 2 gene type, ten for WW gene type and ten for MM gene type. Omeprazole used as probe drug of CYP2C19, the effect of Modified Xiaoyao pill on the activity of CYP2C19 were investigated. Genetic classification was fulfilled by pyrosequencing method, and the blood concentration of probe drug and its metabolic product were determined by HPLCMS/MS. RESULTS: The volunteers took Modified Xiaoyao pill for two weeks, AUC0-12 was used as the standard of the activity of CYP2C19. The activity value was 5.7±1.6 before drug and 6.0±1.7 after drug using. So the activity of CYP2C19 was increased after drug using, t-test was used for comparison, there was no remarkable difference between the data. CONCLUSION: Modified Xiaoyao pill has no obvious affection on the activity of CYP2C19.关键词
加味逍遥丸/CYP2C19/焦磷酸测序Key words
Modified Xiaoyao pill/CYP2C19/ Pyrosequencing分类
医药卫生引用本文复制引用
赵钢涛,杨凡,许茜,丁媛媛,郑绯,许景峰..加味逍遥丸对CYP2C19酶活性的影响[J].中国临床药理学与治疗学,2011,16(4):407-411,5.
