重庆医学2011，Vol.40Issue(22)：2199-2201,2205,4.DOI:10.3969/j.issn.1671-8348.2011.22.006
宁血饮对ITP模型小鼠血小板系统和免疫功能的影响
Effects of Ningxueyin on platelet system and immune function of mice in ITP model
摘要
Abstract
Objective To view the effects of Ningxueyin on platelet system and immune function of mice in idiopathic thrombo cytopenic purpura(ITP) model. Methods The ITP model was established and the mice were divided into 5 groups: blank control group, model group, platelet capsule group, low and high dose Ningxueyin groups. Drugs were administrated in each group 7 days after the model was established. Platelet count, peripheral blood T lymphocyte subsets and platelet associated antibodies in peripheral blood platelet were tested. Megakaryocyte and giant middle plate were accounted; spleen was weighed and its coefficient was calculated. Results In high-dose Nih xue yin group,platelet count was increased, megakaryocyte count was reduced but giant middle plate count was increased. The level of platelet associated antibodies was lower. Spleen weight and spleen coefficient were decreased. T lymphocyte subsets disorder were improved, significantly different from those of control group(P＜0. 05). In platelet capsule group, platelet count was increased, megakaryocyte count was reduced but giant plate count was increased, significantly different from those of control group(P＜0.05). In low-dose Nih xue yin group, the platelet system was improved, but no significant difference was observed compared with the control group(P＞0.05). Conclusion High-dosed Ningxueyin can obviously regulate the abnormality of platelet and immune-related indicators in ITP mice model. Platelet capsule can only regulate hematopoietic system while low-dosed Ning has no effect on them.关键词
紫癜,血小板减少性,特发性/小鼠/血小板/免疫Key words
purpura/ thrombocytopenic/ idiopathic/ mice/ blood platelets/ immunity引用本文复制引用
杨艳梅,熊德上,徐酉华,于洁,戴碧涛..宁血饮对ITP模型小鼠血小板系统和免疫功能的影响[J].重庆医学,2011,40(22):2199-2201,2205,4.基金项目
重庆市卫生局立项课题(2005-B-42). （2005-B-42）
