摘要
Abstract
Objective : To investigate the cervical cancer and cervical intraepithelial neoplasia tissue mPGES-l expression with pathological characteristics and the relationship between cell differentiation and analysis of mPGES-1 and COX-2 relevance. Method: Real-time fluorescence quantitative PCR method , were used to detect cervical cancer surgery in our hospital and all levels of cervical intraepithelial neoplasia tissue mPGES-1 and COX-2 mRNA, analysis of mPGES-1 and COX-2 related as well as the type of pathology ,classification relationship.Result:The cervical cancer and cervical intraepithelial neoplasia tissue mPGES-1 and COX-2 expression was significantly increased, respectively , 110 times the normal tissue and 25 times,both mRNA expression and tumor histological type or grading associated with low differentiation and malignant tumor tissue with high expression of high. In the lesions of mPGES-1 and COX-2 expression was positive correlation. Conclusion : mPGES-1 in mRNA in cervical intraepithelial neoplasia and cervical tissues were significantly higher than benign organizations, and the pathological type , grading, and COX-2 expression was positive correlation. This study has important clinical significance for cervical cancer and cervical intraepithelial neoplasia diagnosis and treatment of the development of new drugs.关键词
膜结合型PGES-1/环氧合酶-2/宫颈癌与宫颈上皮内瘤变Key words
PCES-1 /COX-2 / Cervical cancer and cervical intraepithelial neoplasia分类
医药卫生
