现代妇产科进展2011，Vol.20Issue(5)：369-371,376,4.
CYP1A1基因MspⅠ位点多态性与子宫肌瘤易感性的研究
Correlation of CYP1A1 Msp Ⅰ polymorphism with the susceptibility of the uterine leiomyoma
周超 1林林 2南芳芳 3徐天和 4张磊磊 3张英姿3
作者信息
- 1. 滨州医学院临床学院,滨州256603
- 2. 滨州医学院卫生管理学院
- 3. 滨州医学院附属医院妇产科
- 4. 中国医院统计研究所
- 折叠
摘要
Abstract
Objective : To study of the relationship between CYP1 A1 genetic polymorphism and uterine leiomyoma in Northem QiLu,about Han people. Methods : Msp Ⅰ genotypes of CYP1A1 gene were detected with the methods of PCR-RFLP a case-control study,including 123 cases of uterine leiomyoma and 123 cases as controls. Multivariate logistic regression analysis was used to estimate uterine leiomyoma risk associated with environmental exposures by SULT1A1 genotype. Results : ( 1) There was no significant correlation between uterine leiomyoma group and control group in Msp Ⅰ polymorphism(P=O. 927) . (2) Contrast with T/T genotype,T/C and C /C , the difference between the case and control group all were no significant ( P = 0. 738 , P= 0. 947 , respectively ) . ( 3) Contrast with T/T genotype , merging T/C and C /C ,the difference between the case and control group was no significant ( P=O. 925 ) . Condusions :The results do not imply that CYP1A1 polymorphism of Msp Ⅰ is associated with susceptibility of uterine leiomyoma,in Northem QiLu , about Han people.关键词
细胞色素P450 1A1/子宫肌瘤/基因/多态性Key words
Cytochrome P450 1A1 / Uterine leiomyoma/ Gene / Polymorphism分类
医药卫生引用本文复制引用
周超,林林,南芳芳,徐天和,张磊磊,张英姿..CYP1A1基因MspⅠ位点多态性与子宫肌瘤易感性的研究 [J].现代妇产科进展,2011,20(5):369-371,376,4.
