重庆医学2011，Vol.40Issue(22)：2188-2190,封2,4.DOI:10.3969/j.issn.1671-8348.2011.22.002
肝硬化大鼠肝部分切除后IL-6/STAT3信号通路的变化
Changes in IL-6/STAT3 signal pathway after partial hepatectomy in rats with cirrhosis
摘要
Abstract
Objective To analyze the changes of IL-6/STAT3 signal pathway after partial hepatectomy in rats with CCl4-induced cirrhosis.Methods Cirrhosis was induced in rats by hypodermic injection of CCl4.Untreated rats were used as controls.The control rats and the cirrhotic rats were subjected to 70％ partial hepatectomy.At different time points after hepatectomy,the residual liver and blood samples were collected,the levels of IL-6 and TNF-α in serum, the expression of PCNA and active STAT3 proteins in the liver tissue were analyzed.Results 24 h after hepatectomy, we detected significantly lower mitotic index and PCNA positive cells in the cirrhotic rat as compared to the controls.The cirrhotic rat expressed significantly lower levels of IL-6 as compared to the controls up to 12 h after hepatectomy.Significantly lower levels of active STAT3 proteins were also observed in the cirthotic rat 2 h after hepatectomy.Conclusion The data from our study shows that one of the most important reasons for the impaired liver regeneration in cirrhotic remnants is associated with low expression of IL-6 in the early stage and the following low activation of STAT3 proteins.关键词
肝硬化/肝再生/肝切除术/大鼠,裸Key words
liver cirrhosis / liver regeneration/ hepatectomy / rats , nude引用本文复制引用
袁晟光,农卡特,廖维甲,覃理灵,王莉..肝硬化大鼠肝部分切除后IL-6/STAT3信号通路的变化[J].重庆医学,2011,40(22):2188-2190,封2,4.基金项目
广西科学研究与技术开发计划应用基础研究专项资助项目(桂科基0575108). （桂科基0575108）
