中国中西医结合杂志2011，Vol.31Issue(5)：631-634,4.
黄芪注射液对婴儿先天性心脏病体外循环术后肾损伤的干预作用
Intervention of Astragalus Injection on the Kidney Injury after Cardiopulmonary Bypass of Infants with Congenital Heart Disease
提运幸 1潘征夏 1吴春 1王刚 1李洪波 1李勇刚 1安永 1代江涛1
作者信息
- 1. 重庆医科大学附属儿童医院心胸外科,重庆,400014
- 折叠
摘要
Abstract
Objective To study the intervention of Astragalus Injection in the kidney injury of infants with congenital heart disease after cardiopulmonary bypass, thus providing a new method for protection of the kidney injury in them. Methods Forty infants undergoing cardiac surgery with cardiopulmonary bypass were randomly assigned to the test group and the control group, twenty in each group. Astragalus Injection (at the dose of 2 mL/kg) was added in the perfusion fluid before giving to infants in the test group before bypass, while the normal saline of the same volume was added in the perfusion fluid before giving to infants in the control group ( P＜0. 01 ). The concentrations of serum tumor necrosis factor-α (TNF)-α, interleukin-6 ( IL-6), cystatin C (CysC), and N-acetyl-beta-D-glucosaminidase (NAG) were detected with ELISA at the following time points, i.e.before bypass (T1), by the end of the surgery (T2), 2 h after surgery (T3), 6 h after surgery (T4), and 24 h after surgery (T5). Results The serum CysC concentrations were not significantly higher after CPB ( P＞O. 05).The urinary NAG level increased significantly in the control group after surgery ( P ＜ 0. 05), but no obvious increase of the urinary NAG level was found in the test group after surgery (P＞0.05). It was obviously lower than that of the control group ( P＜0. 05). After CPB serum TNF-α and IL-6 levels increased significantly in the control group (P＜0. 05), while they were lower in the test group than in the control group (P ＜ 0. 01 ). Conclusions CPB may result in the renal tubular injury in infants with congenital heart disease. The application of Astragalus Injection before the CPB plays a role in protecting renal tubular functions.关键词
肾损伤/体外循环/黄芪注射液/婴儿/先天性心脏病Key words
kidney injury/ cardiopulmonary bypass/ Astragalus Injection/ infant/ congenital heart disease引用本文复制引用
提运幸,潘征夏,吴春,王刚,李洪波,李勇刚,安永,代江涛..黄芪注射液对婴儿先天性心脏病体外循环术后肾损伤的干预作用[J].中国中西医结合杂志,2011,31(5):631-634,4.
