摘要
Abstract
Objective To compare the clinical value of common screening methods in the early diagnosis of cervical cancer.Methods A total of 1 000 cases of outpatient who underwent pap smear cytological examination, liquid base cytological ( TCT ) examination, colposcopy ( COL ), and HPV immunohistochemical detection at our cervical clinic between April 1st, 2010 and November 30th, 2010 were enrolled.Sensitivity ( Se ), specificity ( Sp ), positive predictive value ( PPV ), and negative predictive value ( NPV ) among these inspection methods were compared, with pathological examination deemed as the gold standard.Results Se of cervical pap smear cytological examination, liquid base cytological examination, colposcopy, and HPV detection were 44.4％ , 86.8％ , 53.1％ , and 98.0％ ; Sp were 96.1％ , 91.9％ , 83.1％ , and 94.8％ ; E value were 89.7％ , 91.1％ , 80.2％ , and 95.1％ ; PPV were 62.1％ , 66.0％ , 25.5％ , and 67.1％ ; NPV were 92.4％ , 97.5％ ,94.2％ , and 99.8％ , respectively.Se for pap smear - TCT and COL - TCT combination were 74.3％ and 92.9％ ; NPV were95.6％ and 97.9％ ; Sp were 67.8％ and 68.0％ , respectively.Conclusion Liquid base cytological examination and HPV immunohistochemical detection showed the supreme accuracy, while joint inspection might yield higher sensitivity with declined rate of missed diagnosis.Joint inspection of liquid base cytology and colposcopy is worth promotion.关键词
宫颈肿瘤/筛查/诊断技术和方法Key words
Uterine cervical neoplasms/ Screening/ Diagnostic techniques and methods分类
医药卫生
