解放军医学杂志2011，Vol.36Issue(5)：431-436,6.
羟基磷灰石涂层人工假体的涂层附着力及其生物力学行为研究
Adhesive strength of hydroxyl apatite (HA) coating and biomechanics behavior of HA-coated prosthesis: an experimental study
张天阳 1段永宏 1朱澍 2朱锦宇 1朱庆生1
作者信息
- 1. 710032,西安,第四军医大学西京医院全军骨科研究所
- 2. 710032,西安第四军医大学口腔医学系
- 折叠
摘要
Abstract
Objective To explore the influence of adhesive strength of hydroxyapatite (HA) coating on the post-implantation stability of HA-coated prosthesis. Methods The adhesive strength and biomechanics behavior of HA coating were studied by histopathological observation, material parameters and biomechanical testing, the titanium (Ti)-coated prosthesis was employed as control.Results Scratch test showed that the adhesive strength of HA coating was significantly lower than that of Ti coating (P＜0.01).Histopathological examination and bone morphometry showed that, at the early stage of prosthesis implantation, the bony growth around HA-coated prosthesis was significantly higher than that around Ti-coated prosthesis (P＜0. 01), but the ultimate shear strength of HA-coated prosthesis was much lower than that of Ti-coated prosthesis (P＜0. 01). After the push-out test with prosthesis, histopathological observation showed that there were accumulations of clump- and strip-like granular residues on the surface of bones that newly grew around the HA-coated prosthesis, and surface energy-dispersive X-ray spectroscopy (EDX) analysis also confirmed that the shear stress induced HA decohesion from the substrate of prosthesis. Conclusions Although HA coating showed a satisfactory effect on early bone formation and prosthetic stability, due to the deficiencies of adhesive strength, the early stability of prosthesis may be gradually destroyed by the shear loads of human body and coating degradation.关键词
羟基磷灰石类/包被物质,生物相容性/人工关节/生物力学Key words
hydroxyapatites/ coated materials, biocompatible/ joint prosthesis/ biomechanics分类
医药卫生引用本文复制引用
张天阳,段永宏,朱澍,朱锦宇,朱庆生..羟基磷灰石涂层人工假体的涂层附着力及其生物力学行为研究[J].解放军医学杂志,2011,36(5):431-436,6.
