中国全科医学2011，Vol.14Issue(21)：2370-2372,3.
新诊断2型糖尿病患者血清视黄醇结合蛋白4和游离脂肪酸水平变化及其与胰岛素敏感性的关系研究
Changes of Serum Retinol Binding Protein 4 and Free Fatty Acids Levels among Newly Diagnosed Type 2 Diabetic Patients and the Correlations with Insulin-sensitivity
摘要
Abstract
Objective To explore the levels of serum retinol binding protein 4 ( RBP4 ) and free fatty acids ( FFA ), as well as the relationships between RBP4 level, FFA level and insulin - resistance index ( ISI ) in newly diagnosed type 2 diabetic patients.Methods Both Newly diagnosed type 2 diabetes patients ( T2DM, n = 76 ) and healthy subjects ( NC, n = 30 ) were enrolled grouping this study, with their serum levels of RBP4 and FFA measured.Also, insulin resistance index ( HOMA -IR ) and insulin sensitivity ( ISI) were calculated in both groups.Results ( 1 ) Serum levels of RBP4 and FFA in the T2DM group were significantly higher than in the control group ( P ＜0.01 ).(2) Single - factor correlation analysis showed that serum RBP4 was positively correlated with BMI, triglyceride ( TG ), cholesterol ( TC ), HOMA - IR and FFA and negatively correlated with ISI and HOMA - 尾 ( P ＜ 0.05 ).(3) Multielement stepwise regression analysis discoveryed that HOMA - 尾 and FFA were independent risk factors of elevated RBP4 levels.Conclusion Serum RBP4 and FFA levels are significantly elevated among T2DM patients.The high expression level of serum RBP4 is associated with glucose and lipid metabolism which in turn leads to the development of IR and contributes to the pathogenesis of type 2 diabetes.RBP4 and FFA might be synergistic factors in emergence the insulin resistance.关键词
糖尿病,2型/视黄醇结合蛋白4/脂肪酸,非酯化/胰岛素敏感性指数Key words
Diabetic mellitus, type 2/ Retinol - binding protein 4/ Fatty acids, nonesterified/ Insulin - resistance index分类
医药卫生引用本文复制引用
潘佳秋,王慧慧,张超,于学静,姜飞飞..新诊断2型糖尿病患者血清视黄醇结合蛋白4和游离脂肪酸水平变化及其与胰岛素敏感性的关系研究[J].中国全科医学,2011,14(21):2370-2372,3.基金项目
黑龙江省卫生厅课题(2009-323) （2009-323）
