摘要
Abstract
Objective To observe the postoperative survival and quality of life in patients with primary bladder cancer receiving different chemotherapy regimens.Methods A total of 116 patients who met the inclusion criteria were randomized into two groups ( 58 cases each ), with the observation group underwent a long - term postoperative infusion chemotherapy regimen and the control group underwent a short - term infusion chemotherapy.The drugs were diluted to 50 mL with distilled water and in-travesical chemotherapy was performed after emptying the bladder with the drugs retained for 60 minutes.The patients were told to change the position every 15 minutes.Clinical efficacy, survival, adverse effects and quality of life improvement were compared between the two groups.Results Clinical efficacy between the two groups showed significant differences ( P ＜ 0.05 ).Five -year survival rate was 48.3％ for the observation group and 22.4％ for the control group ( P ＜0.05 ).Quality of life score between the both groups showed no significant differences ( P ＞ 0.05 ) before treatment; quality of life score between the both groups showed significant differences ( P ＜ 0.05 ) after treatment.Hematologic toxicity and gastrointestinal reactions, represented by leukopenia, thrombocytopenia, anemia, nausea, vomiting, liver dysfunction, renal dysfunction, peripheral nerve toxicity, and alopecia, were the main side effects for both groups.Incidence of leukopenia, anemia recurrence, and peripheral nerve toxicity were higher in the control group than the observation group ( P ＜ 0.05 ).Conclusion The modified long - term infusion chemotherapy can improve the clinical efficacy, quality of life, as well as survival status of the patients.关键词
膀胱肿瘤/化疗/生活质量/生存期Key words
Urinary bladder neoplasms/ Chemotherapy/ Quality of life/ Survival分类
医药卫生
