中国全科医学2011，Vol.14Issue(21)：2417-2420,4.
DNA修复基因XRCC1的194位点多态性与晚期非小细胞肺癌铂类化疗敏感性关系的Meta分析
Relationship between Arg194Trp Polymorphism of XRCC1 Gene and Sensitivity of Advanced Non-small Cell Lung Cancer towards Platinum-based Chemotherapy:A Meta Analysis
李文骏 1向华 1马庆波1
作者信息
- 1. 400016,重庆市,重庆医科大学医学检验系,临床检验诊断学教育部重点实验室
- 折叠
摘要
Abstract
Objective To explore the relationship hetween Arg194Trp polymorphism of XRCC1 gene and sensitivity of advanced lung cancer to wards platinum - based chemotherapy.Methods Literatures dated from January 1990 to January 2010were collected via searching databases including VIP, CNKI, CBM, Wanfang database, PubMed and EBSCO.The fixed effect model was employed for the subsequent analysis.Results A total of 915 cases from 7 trials were included in the analysis.The pooled OR values for Arg/Trp and Trp/Trp compared with Arg/Arg were 2.63 [95％ CI ( 1.96 , 3.53 )]and 2.27 [95％ CI( 1.45 , 3.56 )]respectively.Conclusion Polymorphism of XRCCl Arg194Trp is associated with better response to platinumhased chemotherapy in advanced lung cancer patients.关键词
XRCC1/多态性,单核苷酸/癌,非小细胞肺/铂化合物/Meta分析Key words
XRCC1/ Polymorphism, single nucleotide/ Carcinoma, non - small - cell lung/ Platinum compounds/Meta - analysis分类
医药卫生引用本文复制引用
李文骏,向华,马庆波..DNA修复基因XRCC1的194位点多态性与晚期非小细胞肺癌铂类化疗敏感性关系的Meta分析[J].中国全科医学,2011,14(21):2417-2420,4.
