四川大学学报（医学版）2011，Vol.42Issue(3)：397-400,4.
地震创伤后应激障碍患者脑静息态默认网络研究
Study on Resting-state Default Mode Network in Patients with Posttraumatic Stress Disorder after the Earthquake
武瑞芝 1张俊然 2邱昌建 1孟雅婧 1朱鸿儒 1龚启勇 2黄晓琦 2张伟1
作者信息
- 1. 四川大学华西医院心理卫生中心,成都610041
- 2. 四川大学华西医院放射科华西磁共振研究中心,成都610041
- 折叠
摘要
Abstract
Objective To explore the pathogenesis of posttraumatic stress disorder (PTSD) by studying default mode network during the resting state in patients with PTSD after homologous traumatic experience.Methods Seventeen PTSD patients and 20 matched normal controls received the examnation of resting-state fMRI scanning.Left and right posterior cingulate cortex was regarded as seed region respectively, and the functional connectivity about whole brain was assessed by using resting-state functional connectivity analysis.Results Compared with control group, the patients with PTSD showed that the brain area with decreased functional connectivity included left superior frontal gyrus and right fusiform gyrus, while the brain area with increased functional connectivity included right precuneus, right superior temporal gyrus and right middle temporal gyrus.Conclusion The brain default mode network of PTSD patients is abnormal in resting state.These abnormalities might be the neuropathological mechanisms of PTSD.关键词
创伤后应激障碍/大脑/默认网络/静息态/地震Key words
Posttraumatic stress disorder/ Brain/ Default mode network/ Resting-state Earthquake引用本文复制引用
武瑞芝,张俊然,邱昌建,孟雅婧,朱鸿儒,龚启勇,黄晓琦,张伟..地震创伤后应激障碍患者脑静息态默认网络研究[J].四川大学学报（医学版）,2011,42(3):397-400,4.
