中国医科大学学报2011，Vol.40Issue(6)：497-500,511,5.DOI:CNKI:21-1227/R.20110602.1649.029
α-2,3-唾液酸糖基转移酶ST3家族分子序列生物信息学分析
Bioinformatics Analysis on the Molecular Sequence of B-gahctosiae α-2,3-sialyltransferase Family
摘要
Abstract
Objective To compare the homology in homo sapiens alpha-2,3-sialyltransferase family and study the patterns of its revolution and its functional correlation. Methods Homology and domain analysis of nucleic acid and protein sequences of beta-galactoside alpha2,3-sialyltransferase family was conducted by using online data base and bioinformatics software,and phylogenetic tree was constructed. Results The primary and secondary structures of alpha-2,3-sialyltransferase family showed high homology. The phylogenetic analysis showed that they were derived from a common ancestor but diverged at different times. Conclusion All members of alpha-2,3-sialyltransferase come from the same family of a common ancestor, and their evolution was in a divergent pattem. The substrate specificity of the family subunits may be related to the glycosylation sites.关键词
a-2,3-唾液酸糖基转移酶/同源性分析/结构域/系统进化树Key words
beta-galactoside alpha-2,3-sialyltransferase/ homology analysis/ domain/ phylogenetic tree分类
生物科学引用本文复制引用
马汝海,钟连生,潘忠诚,王天骄,何群..α-2,3-唾液酸糖基转移酶ST3家族分子序列生物信息学分析[J].中国医科大学学报,2011,40(6):497-500,511,5.基金项目
国家自然科学基金资助项目(20672144) （20672144）
