中国医科大学学报2011，Vol.40Issue(6)：504-507,4.DOI:CNKI:21-12271R.20110602.1649.031
急性脑静脉性血栓形成磁共振功能成像的实验性研究
fMRI of Acute Cerebral Venous Thrombosis and Pathologic Changes: An Experimental Study
摘要
Abstract
Objective To explore the method of functional magnetic resonance imaging (fMRI) in the the diagnosis of acute cerebral venous thrombosis (CVT) and to further study pathophysiological mechanisms of acute CVT through MR images and histological changes.Methods A rat model of acute cerebral venous thrombosis was established by injecting thrombus formation factor 150 μl. fMRI was performed at different postoperative time points and comparison was made with pathological results. Results All visible lesions of MR examination were restricted in the domain of SSS ligated,and the size of lesions varied at different time points. Diffusion-weighted imaging (DWI) was more sensitive to discover lesions than T2WI at 0.5 h,1 h,3 h time point. At 6 h,12 h,24 h,48 h time point,area of lesions on DWI and T2WI had no difference(P＞ 0.05). At each time point,peffusion defect on perfusion-weighted imaging (PWI) was well correlated with lesions on DWI and T2WI. ADC values decreased to (58.8±3.3)％ of normal at the 0.5 h time point,but the value gradually increased after that; and the value increased to (83.1±4.6)％ of normal at the 48 h time point. There was a high degree of consistency between the MR and microscopic findings. Conclusion MRI is an optimal method of studying pathophysiological mechanisms of cerebral vascular diseases.fMRI could be used to monitor the temporal course and appearance of the genesis and development of experimental CVT.关键词
磁共振成像/弥散加权/灌注加权/脑静脉血栓形成Key words
magnetic resonance imaging/ diffusion-weighted/ perfusion-weighted/ cerebral venous thrombosis分类
医药卫生引用本文复制引用
刘文源,赵明光,阎雪晶,杨本强,邹明宇,张立波..急性脑静脉性血栓形成磁共振功能成像的实验性研究[J].中国医科大学学报,2011,40(6):504-507,4.基金项目
辽宁省自然科学基金资助项目(20061031) （20061031）
