中国医科大学学报2011，Vol.40Issue(6)：549-552,4.DOI:CNKI:21-1227/R.20110602.1644.014
结肠癌术后早期肝转移的相关基因分析
The Study on Genes Associated with Early-stage Liver Metastasis after Colorectal Cancer Surgery
摘要
Abstract
Objective To explore genes related to early-stage liver metastasis from colorectal cancer and provide the theoretical basis for the early diagnosis of liver metastasis from colorectal cancer. Methods The RT2 ProfilerTM PCR Array Human Tumor Metastasis ( PAHS-028A ) chip was used to screen differential genes in the primary tumor and the liver metastases. Results It was found that the following genes were expressed at significantly higher levels in the primary tumors of colorectal cancer than in the liver metastatic nodules:ACTB,APC , CTNNA1 , NR4A3 , MMP10 , CTSL1 , RB1 , HPSE , ETV4 , GNRH1, CDKN2A , KISS1R , IL8RB , ITGA7 , ITGB3 , DENR , RPSA , CXCR4 ,MYCL1, NME2,PNN,SMAD2, 4 , MMP11 ,SRC,RORB ,SSTR2,SYK, TCF20, MMP3 , TIMP2,3 , 4 and TIPM1. The following genes were expressed higher in liver metastases than in the primary tumor:MMP9,FN1,CST7,CCL7 and MGAT5.Conclusion Screening for genes related to early-stage liver metastasis genes may provide basis for making gene chips of early-stage liver metastasis from colorectal cancer.关键词
结肠癌/肝转移/转移相关基因/基因芯片Key words
colorectal cancer/ liver metastasis/ metastasis related genes/ gene chips分类
医药卫生引用本文复制引用
蔡相军,王福荣,王春喜,王斌,熊仁青,刘彩刚,冷晗..结肠癌术后早期肝转移的相关基因分析[J].中国医科大学学报,2011,40(6):549-552,4.基金项目
沈阳市科学技术计划资助项目(071995) （071995）
