实用妇产科杂志2011，Vol.27Issue(5)：350-354,5.
子宫内膜异位症局部雌激素代谢酶的表达及意义
Local Expression and Significance of Steroid Metabolizing Enzymes in Endometriosis
摘要
Abstract
Objective: To investigate the estrogen metabolism in matched ectopic and eutopic tissue from patients with endometriosis and in normal endometrium. Methods: P450 aromatase (P450A) mRNA and protein、17β-Hydroxysteroid dehydrogenase 2 (17β-HSD Ⅱ ) mRNA expression in eutopic and ectopic endometrium of patients with endometriosis (n = 67) and in normal endometrium from control group (n = 35)were detected by reverse transcription-polymerase chain reaction and immunohistochemistry. Results: ①P450AmRNA was not expressed in control group, but 17β-HSD Ⅱ mRNA was detected weakly at late proliferative phase and gradually increased to peak in the late secretory phase. ② P450AmRNA and protein were weakly expressed in eutopic tissue of endometriosis, while the expression of 17β-HSD Ⅱ mRNA in eutopic tissue was similar to that of control group, except its intensity was lower than that of normal control. ③ All ectopic tissue in 67 cases of endometriosis presented P450AmRNA and protein expression, but the expression of 17β-HSD Ⅱ mRNA was absent. Conclusions: The ectopic endometrium of endometriosis can produce estrogen by itself, but the metabolism is defecit, so the local consistant estrogen concentration might be the reason of growth of ectopic endometrium.关键词
子宫内膜异位症/芳香化酶,17β-羟基类固醇脱氢酶/雌激素Key words
Endometriosis/ P450 aromatization enzyme/ 17β-hydroxysteroid dehydrogenases/ Estrogen metabolism分类
医药卫生引用本文复制引用
曲军英,欧湘红,林经安,杨代兴,马炎辉..子宫内膜异位症局部雌激素代谢酶的表达及意义[J].实用妇产科杂志,2011,27(5):350-354,5.基金项目
福建省自然科学基金资助(C054004) （C054004）
