内科理论与实践2011，Vol.6Issue(3)：188-191,4.
θ短阵快速脉冲重复经颅磁刺激治疗抑郁症
Theta-burst repetitive transcranial magnetic stimulation in treatment of depression: a randomized double blind controlled trial
摘要
Abstract
Objective To evaluate the safety and efficacy of a novel paradigm of intermittent θ-burst transcranial magnetic stimulation (iTBS) in the treatment of patients with depression. Methods Forty-four consecutive patients with Chinese Classification of Mental Disorders (CCMD)-3 diagnosis of depression were allocated randomly into 2 groups: iTBS group (n=21) and conventional repetitive transcranial magnetic stimulation (rTMS) group (n=23). All patients were treated for 2 weeks. Efficacy and safety rating scales were assessed at three time points, before TMS (baseline), at day 7 and 14.Results In iTBS group, 3 patients were dropped with a drop rate of 14％, while 5 patients were dropped in conventional group with a drop rate of 22％; 36 patients had completed the 2 weeks treatment. After 2 weeks treatment, the improvement rates of Hamilton rating scale for depression (HAMD) in iTBS and conventional groups were 35.13％(34.46％) and 24.62％ (29.05％), respectively. Clinical global impression (CGI) efficacy rate was 56％ in both groups. No statistically significant differences in efficacy and improvement of recognition function were seen between the two groups.No severe adverse effects were observed. Conclusions iTBS has comparative efficacy and safety as the conventional rTMS yet the stimulation intensity was lower and the course of time was shorter.关键词
抑郁症/重复经颅磁刺激/θ短阵快速脉冲模式/疗效Key words
Depression/ Repetitive transcranial magnetic stimulation/ θ-burst transcranial magnetic stimulation/Curative effect分类
医药卫生引用本文复制引用
李惠,徐冰清,李春波,刘登堂,江开达,徐一峰,王继军..θ短阵快速脉冲重复经颅磁刺激治疗抑郁症[J].内科理论与实践,2011,6(3):188-191,4.基金项目
上海市科委重点科技攻关项目(项目编号:074119520) （项目编号:074119520）
上海市卫生局青年基金(项目编号:2008Y054) （项目编号:2008Y054）
上海市科学技术委员会基金(项目编号:10411966400) （项目编号:10411966400）
