内科理论与实践2011，Vol.6Issue(3)：204-207,4.
丹参酮治疗高血压肾病的临床研究
Clinical study of hypertensive nephropathy treated with tanshinone
朱宏文 1朱明 1高建东2
作者信息
- 1. 上海市嘉定区安亭医院内科,上海,201805
- 2. 上海中医药大学附属曙光医院肾内科,上海,200021
- 折叠
摘要
Abstract
Objective To study the effect of tanshinone on treatment of hypertensive nephropathy. Methods Sixty hypertensive nephropathy (chronic kidney disease Ⅰ-Ⅲ stage) patients with losartan as basic treatment were enrolled and divided randomly into 2 groups: basic treatment control group and tanshinone treatment group. After 2 weeks of treatment, the blood pressure, renal function, 24 h proteinuria, and N-acetyl-β-D-glucosaminidase (NAG)were assayed.Results There was no significant difference between the two groups in blood pressure change before and after treatment.After 2 weeks of tanshinone treatment, serum creatinine (SCr) level decreased significantly [from (162.2±10.1) μmol/L to (134.0 ±7.1) μmol/L] and the estimated glomerular filtration rate (eGFR)increased significantly (P＜0.05). SCr level did not change significantly in control group. Urinary protein decreased in each group, and no significant difference was seen between the two groups. Urinary NAG decreased significantly in tanshinone group but not in control group. Conclusions Tanshinone had an effect of protecting renal tubular function and delaying the progression of renal dysfunction. It is safe and may be one of the optional drugs for treatment of hypertensive nephropathy.关键词
高血压肾病/丹参酮/肾功能Key words
Hypertensive nephropathy/ Tanshinone/ Renal function分类
医药卫生引用本文复制引用
朱宏文,朱明,高建东..丹参酮治疗高血压肾病的临床研究[J].内科理论与实践,2011,6(3):204-207,4.
