肿瘤防治研究2011，Vol.38Issue(5)：579-583,5.DOI:10.3971/j.issn.1000-8578.2011.05.027
乙醇脱氢酶2基因多态性与食管癌发病风险的Meta分析
A Meta Analysis on Relationship between Alcohol Dehydrogenase2 Polymorphisms and Risk of Esophageal Cancer
吕鹏 1胡志坚1
作者信息
- 1. 350004,福州,福建医科大学公共卫生学院流行病与卫生统计学系
- 折叠
摘要
Abstract
Objective To study the relationship between ADH2 genetic polymorphisms and susceptibility to esophageal cancer by Meta-analysis. Methods Database from PubMed,CNKI,Wanfang and Vip searches were collected and relevant papers and the literatures were analyzed by Meta analysis. Odds ratio of ADH2 genotype distributions in patients with esophageal cancer and healthy controls was calculated.Heterogeneity test and pooled OR calculation were analyzed by RevMan 5 soft ware. Results Of the case-control studies selected for this Meta analysis, a total of 1 419 esophageal cancer cases and 2 776 controls were included. The pooled Odds Ratio of ADH2 genotype * 1/* 1 vs. * 1/* 2 + * 2/* 2 was 2.83(95％ CI=1.89～4.26);*2/*1vs. *2/*2 was 1.57(95％ CI=1.31～1.88); *1/*1 vs. *2/* 2 was 3.31(95 ％ CI = 1.97～5.59). Conclusion It was demonstrated that there was the relationship between ADH2 genetic polymorphisms and susceptibility to esophageal cancer. In other words, the drinkers carring the ADH2 genotype * 1 associated with the increased risk of esophageal cancer.关键词
食管癌/乙醇脱氢酶2/基因多态性/Meta分析Key words
Esophageal cancer/ ADH2/ Genetic polymorphism/ Meta-analysis分类
医药卫生引用本文复制引用
吕鹏,胡志坚..乙醇脱氢酶2基因多态性与食管癌发病风险的Meta分析[J].肿瘤防治研究,2011,38(5):579-583,5.
