中医学报2011，Vol.26Issue(5)：584-586,3.
益肾活血方对早期糖尿病肾病大鼠作用机制研究
Mechanism Research of Yishenhuoxue Recipe Jether for Early Diabetic Nephropathy in Rats
摘要
Abstract
Objective:To study the the mechanism of action of yiqi huoxue method in formula "benefit of yishenhuoxue recipe" diabetic nephropathy (DN) model of of rats. Methods:Using traditional Chinese medicine Fried liquid filling DN model rats, serve biochemical tests 24 h urine protein experimental rats ,creatinine (Scr), urea nitrogen (BUN), plasma albumin (ALB), blood fat and blood sugar;Leica Qwin Plus image analysis system;glomerular diameter measuring A PAS stain observation rat kidney pathological; Immunohistochemical (IHC) detection kidney tissues TGF- beta 1 expression. Results:The party can reduce experimental rats 24 h urine protein,Scr, BUN, higher ALB, reduce renal glomerulus diameter and heavy, improve renal pathology, reduce the kidney tissues TGF - beta 1 express, the treatment group whether high and low dose group, compared with model groups was statistically significant( P ＜ 0.05 or P ＜0. 01 ), but in the high -dosage groups obvious (P ＜ 0.01 ). Conclusion:The benefit of yishenhuoxue recipe may through the effect of rats in the kidney tissues DN TGF - beta 1 expression, and improve the biochemical indicators, reduce kidney patholosical damage dose - related.关键词
益肾活血方/糖尿病肾病/转化生长因子/实验研究Key words
yishenhuoxue recipe/ diabetic nephropathy ipsos /TGF - beta 1/ experimental research分类
医药卫生引用本文复制引用
宋纯东,薛黎明,孟庆军..益肾活血方对早期糖尿病肾病大鼠作用机制研究[J].中医学报,2011,26(5):584-586,3.基金项目
河南省科技厅资助项目(编号:0412002100) （编号:0412002100）
