肿瘤防治研究2011，Vol.38Issue(5)：539-541,561,4.DOI:10.3971/j.issn.1000-8578.2011.05.015
血清Cyfra21-1和SELDI技术联合检测肺鳞癌的临床意义
Clinical Significance of Cyfra21-1 Analysis Combined with SELDI-TOF-MS Technology in Lung Squamous Carcinoma
摘要
Abstract
Objective To study the diagnostic values of co-detections of traditional serum tumor marker (Cyfra21-1) and serum proteomic patterns by surface-enhanced laser desorption and ionization time-flight mass spectrometry (SELDI-TOF-MS) technology in patients with lung squamous carcinoma.Methods Serum samples of 59 lung squamous carcinoma patients and 60 healthy controls were detected by electrochemiluminescence to analyze the levels of Cyfra21-1, meantime SELDI-TOF-MS and CM10-chips were employed to detect the differential expressions of proteins in serum.Combined with clinical pathological materials, the diagnostic values of two methods combination were evaluated.Results The sensitivity and specificity of Cyfra21-1 detection were 77.966％ and 96.667％, while SELDI-TOF-MS technology were 83.051 ％ and 65.385％.Combined detections of two methods were 94.915％ and 95.000％ respectively.Conclution The sensitivity of co-detection was higher than that of single detection.The specificity of codetection was higher than that of SELDI-TOF-MS technology.关键词
肺鳞癌/SELDI/Cyfra21-1Key words
Lung squamous carcinoma/ SELDI / Cyfra21-1分类
医药卫生引用本文复制引用
刘枋,林志强,陈慧菁,林艳,林丽婷,陈强,叶韵斌..血清Cyfra21-1和SELDI技术联合检测肺鳞癌的临床意义[J].肿瘤防治研究,2011,38(5):539-541,561,4.基金项目
福建省自然科学基金资助项目(X0750024) （X0750024）
