中医学报2011，Vol.26Issue(5)：531-533,3.
青蒿醇提物对H22肝癌小鼠的抑瘤作用研究
Experimental Study on Inhibitory Effect of Artemisia Ethanol Extract on Hepatocarcinoma 22 ( H22 ) In Mice
摘要
Abstract
Objective:To observe the inhibitory effect of Artemisia Ethanol Extract on tumor growth on murine transplanted hepatocarcinoma 22( H22 ) in vivo. Methods:Tumor inhibitory activities were tested in experimental tumor H22 mice. The tumor bearing mice were randomly divided into control group,5 -fluorouracil group (5 -FU ,15 mg/( kg · d)) and Artemisia Ethanol Extract treatment groups (125 my/( kg · d) group,500 ng/( kg · d) group). These mice were given normal saline,or Artemisia Ethanol Extract different doses by gavage respectively once a day for 8 days, while 5 - FU were given by intramuscular injection. Tumor growth state was observed and tumor inhibitory rate was calculated ;To establish an HPLC method for the quantitative determination of the Artemisini in Artemisia Ethanol Extract. Results:Artemisia Ethanol Extract treated groups with different doses could inhibit hepatocarcinoma 22( H22 ) growth ( P ＜0.01 ) ,the inhibitory rate 125 mg/(kg · d) group and 500 mg/(kg · d) group respectively was 54.6％ ,50.6％ ;In the experiment of Artemisinin on tumor growth on murine transplanted hepatocarcinoma 22( H22 ) ,It was showed that Artemisinin did not perform significant antitumor effects on hepatocarcinoma 22( H22 ) at the dose of 10 mg/( kg · d) ;The determination of the Artemisini in Artemisia Ethanol Extract was 0.02％. Conclusion: Artemisia Ethanol Extract can inhibit hepatocarcinoma growth; In addition to Artemisinin, other anti -tumor components may exist in Artemisia annua.关键词
青蒿醇提物/H22肝癌/抑瘤率/小鼠Key words
artemisia ethanol extract/ H22 hepatocarcinoma/ tumor inhibitory rate/ mice分类
医药卫生引用本文复制引用
裴晶,何家靖,朱宇同,杨家庆,李伟,李国桥,宋健平..青蒿醇提物对H22肝癌小鼠的抑瘤作用研究[J].中医学报,2011,26(5):531-533,3.基金项目
国家中药材扶持项目(编号:广东/39) （编号:广东/39）
