安徽医科大学学报2011，Vol.46Issue(9)：846-849,4.
促红细胞生成素对大鼠坐骨神经损伤后背根神经节细胞Bcl-2和Bax表达的影响
Effect of erythropoietin on Bcl-2 and Bax expression of dorsal root ganglion after sciatic nerve injury in rats
摘要
Abstract
Objective To explore the effect of erythropoietin( EPO ) on Bcl-2 and Bax expression of dorsal root ganglion after sciatic nerve injury in rats and provide experimental basis for clinical treatment of peripheral nerve injury. Methods 36 female SD rats were set up the model of the sciatic nerve defect, then the rats were divided into three groups: NS group, EPO group and nerve growth factor( NGF ) group, which were injected intraperitoneally with normal saline, erythropoietin and NFG,respectively. At 7 and 14 days after operation. the rats were taken for morphological assessment. The expression of Bcl-2 and Bax of Ls dorsal root ganglion were observed by immunohistology. Results At 7 and 14 days after operation.the expression of Bcl-2 in EPO group was more than that in NS group( P ＜ 0. 05 ,P ＜0. 01 ).while the expression of Bax in EPO group was less than that in NS group( P ＜ 0. 01 ).There was no significant difference between the EPO group and NGF group. Conclusion EPO can promote the expression of Bcl-2 and inhibit the expression of Bax, which may provide protective effect on sciatic nerve injury in rats .关键词
红细胞生成素/坐骨神经/损伤/神经节,脊/bcl-2相关蛋白Key words
eryhropoietin/sciatic nerve/injuries/genglia,spinal/bcl-2-assciatde protein分类
医药卫生引用本文复制引用
陈健,尹宗生,张辉,胡勇,王伟,钟林..促红细胞生成素对大鼠坐骨神经损伤后背根神经节细胞Bcl-2和Bax表达的影响[J].安徽医科大学学报,2011,46(9):846-849,4.基金项目
教育部科学技术研究重点基金资助项目(编号:207049) （编号:207049）
安徽省科技厅年度重点基金资助项目(编号:07020303070) （编号:07020303070）
