安徽医科大学学报2011，Vol.46Issue(9)：857-861,5.
雷公藤多苷对糖尿病肾病大鼠足细胞的保护作用
Protective effect of TWP on the podocytes of diabetes nephropathy rats
摘要
Abstract
Objective To explore the protective effect of triptergium wilfordii polyglucoside( TWP ) on the podocytes of diabetes nephropathy ( DN ) rats. Methods Sixty SD rats were randomly divided into normal control group( group A ), DN group( group B ) , TWP group ( group C ). Rats in group B and C were given streptozotocin( STZ ) by intraperitoneal injection to establish animal model of diabetes. After 12 weeks . we observed UAER , kidney organization of pathological changes by HE staining, and ultrastructure changes of podocytes by TEM , and expression of the Nephrin and Podocin protein by immunofluorescence staining. Results Compared with group A, UAER were obviously higher (P＜0. 01 ); Nephrin and Podocin protein expressions in nephridial tissue were lower; Pathomorphological change in glomerulus, tubules and podocytes were observed in group B and C. Compared with group B, UAER were obviously lower( P ＜ 0. 01 ) ; Nephrin and Podocin protein expressions in nephridial tissue were higher; Pathomorphologica change in glomerulus, tubules and podocytes showed a better improvement in group C. Conclusion The protective effect of TWP on the podocyte of DN rats may be partly referred with up-regulation of Nephrin andPodocin expressions and improved glomerular podocyte lesion.关键词
糖尿病肾病Key words
disbebic nephropathies分类
医药卫生引用本文复制引用
郑云,郝丽,潘梦舒,丁楠..雷公藤多苷对糖尿病肾病大鼠足细胞的保护作用[J].安徽医科大学学报,2011,46(9):857-861,5.基金项目
安徽省自然科学基金(编号:070413066) （编号:070413066）
