安徽医科大学学报2011，Vol.46Issue(9)：893-896,4.
蜂毒素对胃癌SGC-7901细胞裸鼠移植瘤的抑制作用及其部分机制
Study of melittin on tumor inhibition and partial mechanism of human gastric cancer SGC-7901 cell xenografts in nude mice
楼蓉 1李俊 1吕雄文 1金涌 1赵斌 1吴宝明 1任丹阳 1王亚丽1
作者信息
摘要
Abstract
Objective To explore the effects and mechanism of melittin on tumor growth of human gastric cancer
SGC-7901 cell xenografts in nude mice. Methods The xenografts derived from SGC-7901 cells were established in
nude mice. The effect of melittin on tumor-bearing mice was evaluated by inhibition rate. Phagocytosis of peritoneal
macrophage was measured by neutral red method. NK cell activity was detected by improved MTT assay. Concent
of interleukin-2 ( IL-2 ) in serum was determined by ELISA method. The changes of immunity of tumor-bearing
mice were observed by above-mentioned and organ index. Results Melittin ( 2, 4 mg/kg) could inhibit the tumor
growth, while improve the index of spleen, enhance phagocytosis of peritoneal macrophage and NK cell activity,
and melittin ( 4 mg/kg ) could increase IL-2 level in serum. Conclusion Melittin has significant inhibition on
tumor-bearing mice, which is related to reinforcing the immunity of mice.关键词
蜂毒素/药理学/胃肿瘤/小鼠,裸Key words
melittin/pharmacology/ stomach neoplasms/ mice, nude 分类
医药卫生引用本文复制引用
楼蓉,李俊,吕雄文,金涌,赵斌,吴宝明,任丹阳,王亚丽..蜂毒素对胃癌SGC-7901细胞裸鼠移植瘤的抑制作用及其部分机制[J].安徽医科大学学报,2011,46(9):893-896,4.
