四川中医2011，Vol.29Issue(5)：16-20,5.
TGF-β1在哮喘大鼠模型中动态变化及柴朴汤的干预研究
Dynamic Changes of TGF-βl in Asthma Rats Model and Intervention Study of Chaipu Qecoction
摘要
Abstract
Objective: The purpose of this study was to explore dynamic changes of TGF-β1 in asthma rats model. ChaiPu Qecotion was used to cure bronchial asthma. Methods: The asthma model was copied by using atomization ovalbumin. The thickness of inner-tube of airway and the airway smooth muscle is observed by normal slice. RT-PCR is used to detect the mRNA expression level of TGF-β1.And immunohistochernical staining method was used to detect protein expression of TGF-β1. Results: The thickening of airway smooth muscle appeared on the stimulated rats after 2 weeks. And the airway smooth muscle became thicker with the stimulated time prolonging.The mRNA expression level of TGF-β1 and the protein expression of TGF-β1 in the bronchus lung tissue of asthmatic rats rose with the stimulated time prolonging. And dynamic changes were appeared in airway remodeling in asthma rats model. The expression of TGF-β1 descended after using ChaiPu Qecoction. Conclusion: In the process of airway remodeling in asthma, the expression of TGF-β1 rises with the stimulated time prolonging. It is a dynamic change. ChaiPu Qecotion can be used to inhibit the airway remodeling by descending the expression of TGF-β1.关键词
TGF-β1/哮喘/柴朴汤/气道重塑Key words
TGF-β1 asthma ChaiPu Qecoction airway remodeling分类
医药卫生引用本文复制引用
刘鑫,刘希,彭光耀,黄艳..TGF-β1在哮喘大鼠模型中动态变化及柴朴汤的干预研究[J].四川中医,2011,29(5):16-20,5.基金项目
湖南省中医药管理局科研计划项目(编号:2008015),湖南省教育厅课题(编号:07C628) （编号:2008015）
