中国中西医结合杂志2011，Vol.31Issue(5)：667-671,5.
人参大黄栝蒌角药配伍对动脉粥样硬化进程中血脂四项及相关促炎因子的影响
Effect of Triangle Drugs as Ginseng, Trichosanthes kirilowii Maxim and Rhubarb on the Level of Blood Lipids and Related Pro-inflammatory Cytokines during the Process of Treating Artherosclerosis
摘要
Abstract
Objective To study the effect of triangle drugs as ginseng, Trichosanthes kirilowii Maxim, and rhubarb on the levels of blood lipids as [total cholesterol (TC), triglyeride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)]and pro-inflammatory cytokines as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and high sensitive C reactive protein (hs-CRP)during the process of treating artherosclerosis.Methods Twenty New Zealand rabbits were randomly divided into three groups after one-week adaptive feeding, i.e.the normal control group (n=6), the model group (n=6), and the triangle drugs group (n=8).High fat diet was fed to rabbits in the triangle drugs group and the model group at the daily dose of 100 g for six weeks.Iliac artery was injured in the model group and the triangle drugs group at the seventh week using balloon injury.High fat diet was successively fed to those after surgery for six weeks.At the same time of modeling, preventive medication (at the daily dose of dry ginseng 0.64 g/kg, Trichosanthes kirilowii Maxim 2.14 g/kg,and prepared Radix et Rhizoma Rhei with wine 0.43 g/kg, with the volume of 2 mL/kg) was administered by gastrogavage to rabbits in the triangle drugs group.Changes of blood lipids levels and related pro-inflammatory cytokines were dynamically observed.Results On the 7th week (before surgery), the levels of TC, TG, HDL-C, and LDL-C in the model group, TC, HDL-C, and LDL-C in the triangle drugs group significantly increased, showing significant difference when compared with those of the normal control group ( P＜0.05).The levels of pro-inflammatory cytokines in the model group and the triangle drugs group were significantly higher than those in the normal control group ( P＜0.05).Levels of TC, TG, and LDL-C were lower in the triangle drugs group than in the model group, showing statistical difference (P＜0.05).After the 8th week the levels of blood lipids and ICAM-1 in the model group, and levels of TC, LDL-C,HDL-C, and ICAM-1 in the triangle drugs group were significantly higher than those of the normal control group, showing statistical difference (P＜0.05).After the 12th week levels of blood lipids in the model group, LDL-C and HDL-C in the triangle drugs group were significantly higher than those of the normal control group, showing statistical difference (P＜0.05).The LDL-C level was lower in the triangle drugs group than in the model group, showing statistical difference ( P＜0.05).The levels of VCAM-1, ICAM-1, and hs-CRP in the model group were obviously higher than those in the triangle drugs group and the normal control group, showing statistical significance (P＜0.05).The hs-CRP level was higher in the triangle drugs group than in the normal control group, showing statistical difference (P＜0.05).Conclusions The triangle drugs may postpone the process of artherosclerosis by lowering blood lipids levels, especially by lowering the elevating levels of TC and LDL-C.Its roles in decreasing the level of pro-inflamrnatory cytokines might be associated with lipids lowering and anti-inflammation.Its roles may also be associated with improvement of the endothelial function and inhibition of the smooth muscle proliferation.关键词
动脉粥样硬化/人参/栝萎/大黄/角药/血脂四项/细胞间黏附分子/血管细胞黏附分子/高敏C反应蛋白Key words
artherosclerosis/ ginseng/ Trichosanthes kirilowii Maxim/ rhubarb/ triangle drugs/ four items of blood lipids/ intercellular adhesion molecule-1/ vascular cell adhesion molecule-1/ high sensitive C reactive protein引用本文复制引用
王建云,吴圣贤,姜良铎..人参大黄栝蒌角药配伍对动脉粥样硬化进程中血脂四项及相关促炎因子的影响[J].中国中西医结合杂志,2011,31(5):667-671,5.基金项目
1.国家重大新药创制课题(No.2009ZX09103-318) （No.2009ZX09103-318）
2.北京中医药大学校级课题(No.2007-X-25) （No.2007-X-25）
