中华临床免疫和变态反应杂志2011，Vol.5Issue(2)：83-87,5.
风湿性疾病的T细胞γ干扰素释放分析诊断潜伏性结核分枝杆菌感染
T-cell Interferon-gamma Release Assays to Detect Latent Tuberculosis Infection in Rheumatic Diseases
杨华夏 1张丽帆 1刘晓清 1赵岩2
作者信息
- 1. 中国医学科学院北京协和医学院北京协和医院内科,北京100730
- 2. 中国医学科学院北京协和医学院北京协和医院风湿免疫科,北京100032
- 折叠
摘要
Abstract
Patients with rheumatic diseases are in the immunosuppresive status and anti-TNF therapy may increase the risk of tuberculosis (TB) reactivation. T cell Interferon-γ release assays (IGRA) are more sensitive and specific than tuberculin skin test (TST) to detect latent TB infection (LTBI), especially in the immunosuppresive patients. The limited research data showed the discordance of IGRA and TST in diganosing LTBI. IGRA positive results were more significantly related with clinical risk factors for LTBI. A positive result of IGRA in addition to clinical screening of risk factors for LTBI, will contribute to the detection of LTBI in rheumatic diseases. Preventive treatment of TB should be considered in this high risk population.关键词
风湿性疾病/结核/肿瘤坏死因子α拮抗剂/T细胞γ干扰素释放分析Key words
rheumatic disease/ tuberculosis/ tumor necrosis factor-α antagonists/ T cell interferon-γ release assay分类
医药卫生引用本文复制引用
杨华夏,张丽帆,刘晓清,赵岩..风湿性疾病的T细胞γ干扰素释放分析诊断潜伏性结核分枝杆菌感染[J].中华临床免疫和变态反应杂志,2011,5(2):83-87,5.
