中国肺癌杂志2011，Vol.14Issue(5)：446-451,6.DOI:10.3779/j.issn.1009-3419.2011.05.12
肺粘膜相关淋巴组织边缘区B细胞淋巴瘤的临床病理分析
Clinicopathological Analysis of Pulmonary Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue
陈勃江 1高俊 2唐源 2张尚福 2李为民 1曾静1
作者信息
- 1. 610041,成都,四川大学华西医院呼吸内科
- 2. 610041,成都,四川大学华西医院病理科
- 折叠
摘要
Abstract
Background and objective As a rare disease, pulmonary marginal zone B-cell lymphoma of mucosaassociated lymphoid tissue (PMZL-MALT), is often misdiagnosed.The aim of this study is to summarize the clinical and pathological features of this disease and improve the awareness of doctors.Methods Seven cases (female 5, male 2) diagnosed of PMZL-MALT in West China Hospital between November 2008 and November 2010, were analyzed retrospectively, including their symptoms, radiological findings, pathological examinations, treatment and prognosis.Results The median age of the patients were 62 years old (range 34-79 years).Six patients suffered from cough and sputum.Pulmonary consolidation was the most frequent manifestation, leading a misdiagnosis of pneumonia with CT examinations.Pathological diagnosis was obtained via fiberoptic bronchoscopy in six patients and percutaneous pulmonary biopsy for the rest one.In the seven cases,immunohistochemical results showed CD20(+), CD79a(+), while CD3 epsilon(-), CD5(-), CyclinD1(-), CDIO(-), Bcl-2(-)and CD30 (-).Additionally, the expression of K1-67 was below 10％.Further PCR analysis showed evidence of immunoglobulin heavy chain gene rearrangement in tissues from six subjects.Based on the disease location and patients' wishes, compared with two cases just receiving symptomatic treatments, the other five ones took in chemotherapies.Conclusion Since there were no specific clinical features for patients of PMZL-MALT, histopathological examination was the only effective means to confirm the diagnosis.关键词
肺肿瘤/淋巴瘤/诊断/预后Key words
Lung neoplasms/ Lymphoma/ Diagnosis/ Prognosis分类
医药卫生引用本文复制引用
陈勃江,高俊,唐源,张尚福,李为民,曾静..肺粘膜相关淋巴组织边缘区B细胞淋巴瘤的临床病理分析[J].中国肺癌杂志,2011,14(5):446-451,6.
