中国康复理论与实践2011，Vol.17Issue(5)：433-436,4.
人脑胶质瘤中转化生长因子β2、Smad3蛋白表达及临床意义
Expressions of Transforming Growth Factor β2 and Smad3 in Human Gliomas with Different Pathologic Grade Proliferation and Its Clinical Significance
摘要
Abstract
Objective To investigate the expressions of Transforming Growth Factor β2 (TGF-β2) and Smad3 in human gliomas associated with pathologic grading. Methods The expressions of TGFβ2 and Smad3 protein were detected with SP immunhistochemistry in 80 human glioma specimens. The Kapan-Meier survival curves of progression-free survival time and overall survival time in different expression levels was compared with log-rank. Results The expression of TGFβ2 and Smad3 correlated with the pathological grading (r=0.545, r=0.570, P＜0.01). Both progression-free survival time and overall survival time were significantly different between low expression group and high expression group (P≤0.05). Conclusion Both TGF-β2 and Smad3 correlate well with the occurrence and differentiation of human gliomas, which help for the diagnosis, treatment and prognosis judgment.关键词
脑胶质瘤/转化生长因子β2/Smad3/免疫组织化学Key words
glioma: transforming growth factor β2/ Smad3/ immunhistochemistry分类
医药卫生引用本文复制引用
苏伟,刘福生,朱贵东,姜中利,金贵善,柴奇,曹泽..人脑胶质瘤中转化生长因子β2、Smad3蛋白表达及临床意义[J].中国康复理论与实践,2011,17(5):433-436,4.基金项目
北京市自然科学基金(7102027). （7102027）
