中国康复理论与实践2011，Vol.17Issue(5)：411-414,4.
RELN基因单核甘酸多态性与儿童孤独症临床特征的相关分析
RELN Gene Single Nucleotide Polymorphism Related with Clinical Features of Autism
孙颖 1盛昭明 2刘明远 3杨利敏 3李兴洲 3姜志梅1
作者信息
- 1. 佳木斯大学附属第三医院,黑龙江佳木斯市,154003
- 2. 黑龙江省农垦总局牡丹江分局中心医院康复科,黑龙江牡丹江市,158300
- 3. 佳木斯大学基础医学院,黑龙江佳木斯市,154007
- 折叠
摘要
Abstract
Objective To investigate the relationship between RELN gene single nucleotide polymorphism (SNP) and childhood autism in Jiamusi, Heilongjiang. Methods Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine allele and genotype of SNP (exon 6) of RELN in 30 children with autism and 30 normal children. Autism Behavior Checklist (ABC) was used to evaluate the children. Results There was a significant difference in the distribution of the allelic frequencies and genotype in exon 6between these groups (P＜0.05). There was a significant difference in the communication factors between patients with genotype of A/A and A/G or A/A and G/G (P＜0.05), as well as in the total scores ofABC between A/G and G/G (P＜0.05). Conclusion The SNP of RELN (exon 6) associated with the childhood autism. There is a more serious communication disorder in children with genotype of G/G, A/G than that of A/A.关键词
儿童/孤独症/RELN基因/单核苷酸多态性/孤独症行为检查表Key words
child/ autism/ gene RELN/ single nucleotide polymorphism (SNP)/ Autism Behavior Checklist分类
医药卫生引用本文复制引用
孙颖,盛昭明,刘明远,杨利敏,李兴洲,姜志梅..RELN基因单核甘酸多态性与儿童孤独症临床特征的相关分析[J].中国康复理论与实践,2011,17(5):411-414,4.
