摘要
Abstract
Purpose To investigate the differential diagnosis between adenoid cystic carcinoma ( ACC ) and polymorphous low-grade adenocarcinoma ( PLGA ). Methods 10 cases of PLGA and 12 comparison cases of ACC were retrieved, the comparison of the clinical and histological features in two groups of tumor, immunohistochemical staining for c-kit、galection-3、α-SMA、p63 and Ki-67 were performed. Results The total of PLGA accounted for 6. 9％ of minor salivary gland malignant tumor in the same period, the tumors were all intraoral and 80％ occurred in the palate. Histologically, PLGA shared cribriform, tuhular and solid patterns. infiltrative borders and neurotropism with ACC. However, tumor cells in PLGA were uniform, round to cuhoidal with bland vesicular nuclei, arranged in diverse architectural patterns, including tubular, trabecular, papillary, papillary-cystic, lobular, cribriform, strand-like and so on,the tubules were lined by a single layer of monomorphic tumor cells , single filing of tumor cells and targetoid patterns were usually seen in PLGJA. Immunohistochemical staining showed that expression extent and pattern of the five markers were different in the two tumors.Conclusions PLGA is a rare malignant tumor of minor salivary gland with a predilection for the palate; Histopathological features remain the most reliable criteria to distinguish hetween these two tumours . PLGA is characterized by hland-looking tumour cells and highly variable growth patterns. C-kit、galection-3 、α-SMA、p63 does not appear to be an speical marker for ACC or PLGA, and immunohistochemistry may he only used to support morphologic dignosis as an adjunctive method.关键词
涎腺肿瘤/多形性低度恶性腺癌/腺样囊性癌/免疫组织化学Key words
salivary glands neoplasms/ polymorphous low-grade adenocarcinoma/ adenoid cystic carcinoma/ immunohistochemistry分类
医药卫生
