临床与实验病理学杂志2011，Vol.27Issue(7)：707-711,716,6.
胃肠道间质瘤124例DOG1、WISP-1表达与临床意义
Expression of DOG1 and WISP-1 in gastrointestinal stromal tumors of 124 cases and their clinic significance
摘要
Abstract
Purpose To investigate the expression and clinical significance of DOG1 and WISP-1 in gastrointestinal stromal tumors ( GISTs ). Methods One hundred and twenty - four GISTs with complete clinicopathologic data were retrieved from the archival files of the department of pathology, Affiliated Hospital of North Sichuan Medical College. The expression levels of DOG1 and WISP-1 were detected by immunohistochemistry in 124 cases of GIST tissues, and specimens from non-GISTs were used as controls. Statistical analysis were performed using x2 test and Spearmen test. Result Of 124 GISTs, 119( 96％ ) were positive for DOG1 and 111 ( 91.0％ )for CD117. DOG1 protein expression rate was significantly different between GISTs and non-GISTs ( P ＜ 0. 001 ), but there were no significant differences between DOG1 and CD117 expression in GISTs. As for WISP-1 , this antibody yielded positive staining in 100 0f 124 ( 80. 6％ ) GISTs. The expression rate of WISP-1 protein in very low risk, low risk, intermediate risk, and high risk cases was 44. 4％( 4/9 ),66. 7％( 26/39 ),86. 9％ ( 17/20 ), 95. 0％ ( 38/40 ), and there was a significant correlation between WISP-1 protein expression and the risk score proposed by NIH( 2008 ). Conclusions DOG1 is a sensitivity and specificity marker for GIST and should be used as " the first line" antibody as CD117 protein in routine diagnosis. The expression of WISP - 1 maybe associated with GIST progression and could be used as a prognosis marker in GIST.关键词
胃肠道肿瘤/间质瘤/DOG1/WISP-1/预后Key words
gastrointestinal stromal neoplasms/ stromal tumor/ DOG1 / WISP-1 / prognosis分类
医药卫生引用本文复制引用
蹇顺海,黄一凡,文彬,刘钧..胃肠道间质瘤124例DOG1、WISP-1表达与临床意义[J].临床与实验病理学杂志,2011,27(7):707-711,716,6.基金项目
四川省科技厅资助项目(2009sz0258) （2009sz0258）
