临床与实验病理学杂志2011，Vol.27Issue(7)：742-745,4.
载脂蛋白E基因敲除鼠不同部位动脉粥样硬化病变病理形态学分析
Pathomorphology analysis of atherosclerotic lesion in different site of apolipoproteinE gene knock-out mice
摘要
Abstract
Purpose To analyze the pathomorphology characteristic of atherosclerotic lesion in different site by estahlishing animal model of atherosclerosis in apolipoproteinE gene knock-out mice. Methods ApolipoproteinE gene knock-out mice were fed a westerntype diet and operated with perivascular right common carotid collar placement to establish animal model of atherosclerosis. Serial paraffin sections were routinely stained with hematoxylin and eosin to ohserve atherosclerotic lesion in common carotids and aorta. Results Atherosclerotic lesion in common carotid collar placement was most serious , but there was no atherosclerotic lesion in common carotid non-collar placement. There were ten cases belong to Ⅰ , Ⅱ type atherosclerotic lesion in common carotid collar placement and aorta,fourteen cases in common carotid collar placement but six cases in aorta belong to Ⅲ , Ⅳ , Ⅴ type atherosclerotic lesion. Conclusions Atherosclerotic lesion induced by collar placement in common carotid happens and develops quickly, but spontaneous formative atherosclerotic lesion in aorta grows slowly.关键词
动脉粥样硬化/动物模型/载脂蛋白E基因敲除鼠/病理形态学分析Key words
atherosclerosis/ animal model/ apolipoproteinE gene knock-out mice/pathomorphology analysis分类
医药卫生引用本文复制引用
唐雅玲,黄韬,冬毕华,许增祥,杨永宗..载脂蛋白E基因敲除鼠不同部位动脉粥样硬化病变病理形态学分析[J].临床与实验病理学杂志,2011,27(7):742-745,4.基金项目
湖南省教育厅资助(10C1132) （10C1132）
