摘要
Abstract
OBJECTIVE: To observe the therapeutic efficacy and safety of clopidogrel combined with aspirin in the treatment of unstable angina pectoris. METHODS: 100 patients suffering from unstable angina from Oct. 2009 to Oct. 2010 in our hospital were randomly divided into observation group and control group, with 50 patients in each group. The patients in the control group were treated with aspirin(0.3 g, qd, after 3 d, 0.1 g, qd), while the patients in the observation group were additionally treated with clopidogrel on the basis of aspirin therapy (initial dose was 300 mg and then changed as 75 mg,qd, 6 weeks was 1 course). The therapeutic efficacy and adverse drug reactions of 2 groups were compared. RESULTS: In observation group, 34 cases were markedly effective, 15 cases effective, 1 case invalid with total effective rate of 98.0％; In control group, 14 cases were markedly effective, 22 cases effective, 14 cases invalid with total effective rate of 72.0％. There was significant difference in total effective rate between 2 groups (P＜0.05). But the incidence of cardiac events in observation group including recurrent angina, acute myocardial infarction and sudden cardiac death was significantly lower than in control group (P＜0.05). CONCLUSION: The therapeutic efficacy of clopidogrel combined with aspirin is better and safer than aspirin alone in the treatment of unstable angina.关键词
氯吡格雷/阿司匹林/不稳定型心绞痛/疗效Key words
Clopidogrel/ Aspirin/ Unstable angina/ Therapeutic efficacy分类
医药卫生
