安徽医科大学学报2011，Vol.46Issue(7)：645-647,3.
脓毒症大鼠巨噬细胞炎症蛋白-1α和血管内皮细胞变化及其相关性研究
The study of changes and correlation of serum macrophage inflammatory protein-1α level and vascular endothelial cells in septic rats
摘要
Abstract
Objective To study of changes and correlation of alveolar macrophage( AM ) infammatory protein-1 α ( MIP-1 α ) level and vascular endothelial cells in septic rats of cecal ligation and puncture ( CLP ). Methods 60 SD rats were divided into two groups randomly, group A sham operation group, and group B was sepsis group. Rats of group A only were appendix exploration. the rats received CLP in group B. In each group, the subcutaneous injected saline of 5 ml at the time of respectively. In group A and B, all rats were detected the levels of MIP-1α through bronchial alvolar lavage fluid, E-selectin and TNF-α in serum at 3,6,12,24,48 h. Results ① Compared with group A, the levels of MIP-1α in bronchial alvolar lavage fluid, E-selectin,TNF-α in blood serum were increased significantly in group B( P ＜ 0. 05 ). ②The Bronchial Alvolar Lavage Fluid MIP-1 α and serum E-selectin,TNF-α had obviously correlation. Conclusion In the process of sepsis-induced ALI, the collection of AM and the damages of vascular endothelial have obviously direct correlation. It hints that AM and vascular endothelial may play an important role in sepsis-induced ALI.关键词
脓毒症/趋化因子CCL3/内皮,血管/E选择素/肿瘤坏死因子α/巨噬细胞,肺泡Key words
sepsis/ chemokine CCL3/ endothelium, vascular/E-selectin/ tumor necrosis factor-alpha/macrophages,alveolar分类
医药卫生引用本文复制引用
赵浩东,胡德林,余又新,王春华,占利民,方林森,徐庆连..脓毒症大鼠巨噬细胞炎症蛋白-1α和血管内皮细胞变化及其相关性研究[J].安徽医科大学学报,2011,46(7):645-647,3.基金项目
安徽省卫生厅科研基金 (编号:09A067) （编号:09A067）
