中国病理生理杂志2011，Vol.27Issue(7)：1319-1322,4.DOI:10.3969/j.issn.1000-4718.2011.07.013
精胺对急性脑缺血再灌注损伤大鼠的保护作用
Protective effect of spermine on rats with acute cerebral ischemia/reperfusion injury
摘要
Abstract
AIM: To study the effects and the possible mechanisms of exogenous spermine on the rats with acute transient focal cerebral ischemia/reperfusion ( I/R ) injury.METHODS: The rat model of focal cerebral ischemia/ reperfusion was established by middle cerebral artery occlusion ( 2 h ) and reperfusion ( 2 h ).Healthy adult SD rats were divided into 5 groups; sham group, I/R group and spermine( 4,20 and 40 mmol/L )groups.The degree of cerebral injury was evaluated by neurological deficit score, infracted volume, superoxide dismutase ( SOD ) activity and malondialdehyde ( MDA ) content.The morphological changes of the brain were observed by HE staining and electron microscopy.RESULTS: Compared with I/R group, the neurological deficit score, infracted volume and the content of MDA were decreased , the SOD activity was increased and the ultrastructural changes were improved in spermine - treated groups.CONCLUSION: Exogenous spermine has a protective effect against acute focal cerebral ischemia/reperfusion injury.The mechanisms may be related to scavenging free radical by spermine.关键词
精胺/脑缺血/超氧化物歧化酶/丙二醛/大鼠Key words
Spermine/ Brain ischemia/ Superoxide dismutase/ Malondialdehyde/ Rats分类
医药卫生引用本文复制引用
贾洪丽,徐长庆,赫文,侯俊青,张宁,孔凡娟,郝静辉,孙健,白淑芝,李宏霞..精胺对急性脑缺血再灌注损伤大鼠的保护作用[J].中国病理生理杂志,2011,27(7):1319-1322,4.基金项目
国家自然科学基金资助项目(No.30871012 （）
No.81070123) （）
高校博士点基金资助项目(No.20070226012) （No.20070226012）
