中国病理生理杂志2011，Vol.27Issue(7)：1431-1437,1444,8.DOI:10.3969/j.issn.1000-4718.2011.07.035
MicroRNA在脑胶质瘤中的作用
Roles of microRNAs in glioma
摘要
Abstract
MicroRNAs (miRNAs) are critical regulators of gene expression. These small, non-coding RNAs are believed to regulate more than one third of protein-coding genes, and have been implicated in the control of many biological processes, including the biology of glioma. The functional significance in some of the miRNAs begins to emerge. This paper reviews the biogenesis of miRNAs, their roles in neuronal development and tumorigenesis of gliomas, and their contribution as tumor biomarkers. Research in this area is quickly gathering pace and is illuminating important aspects of the diseases that may ultimately lead to novel therapeutic interventions, as well as diagnostic and prognostic tools for brain tumors.关键词
微小RNA/神经胶质瘤/靶基因Key words
MicroRNA/Glioma/Target gene分类
医药卫生引用本文复制引用
胡婷,钟雪云..MicroRNA在脑胶质瘤中的作用[J].中国病理生理杂志,2011,27(7):1431-1437,1444,8.基金项目
国家自然科学基金资助项目(No.81072059) （No.81072059）
广东省自然科学基金资助项目(No.10151063201000059) （No.10151063201000059）
