中国病理生理杂志2011，Vol.27Issue(7)：1409-1413,5.DOI:10.3969/j.issn.1000-4718.2011.07.030
早期术后肠麻痹小鼠肠系膜传入神经电活动的变化
Changes of mesenteric afferent nerve discharge during early phase of postoperative ileus in mice
摘要
Abstract
AIM: To observe the changes of mesenteric afferent nerve discharge during the early phase of postoperative ileus ( POI ).METHODS: Under enflurane anesthesia, C57BL/6 mice underwent laparotomy followed by sham operation or standardized small bowel manipulation to induce POI.Three hours after operation, extracellular multi - unit mesenteric afferent nerve discharge was recorded ( n = 6 in each subgroup ).RESULTS: Amplitudes of intestinal contractions were ( 0.67 ± 0.03 ) mmHg after POI induction and ( 3.82 ± 0.54 ) mmHg in sham group ( P ＜ 0.05 ).The intestinal afferent firing in response to serosal 5 - hydroxytryptamine ( 5 - HT ) stimulation was followed by a decrease in the mesenteric afferent nerve discharge to(7.5±1.1) imp · s-1 in POI segments, compared with ( 20.5 ±5.5 ) imp · s-1 in sham group ( P ＜0.05 ).During intraluminal distension pressure from 10 to 20 mmHg and from 20 to 30 mmHg, the mesenteric afferent nerve discharges in POI segments were ( 30.8 ±6.6 ) imp · s-1 and ( 41.4 ±6.7 ) imp · s-1 , respectively, lower than those in sham group [( 40.6 ±5.5 ) imp · s-1 and ( 63.9 ±9.6 ) imp · s-1 , respectively, P ＜0.05].CONCLUSION : The mesenteric afferent nerve discharge in response to 5 - HT and low - threshold distension is reduced in the early phase of POI.关键词
手术后肠麻痹/肠系膜传入神经电活动Key words
Postoperative ileus/ Mesenteric afferent nerve discharge分类
医药卫生引用本文复制引用
高志荣,余良英,曹明华,冯佳燕,林旭红,冯雅静,李永渝..早期术后肠麻痹小鼠肠系膜传入神经电活动的变化[J].中国病理生理杂志,2011,27(7):1409-1413,5.基金项目
国家自然科学基金资助项目(No.30971168) （No.30971168）
