中国病理生理杂志2011，Vol.27Issue(7)：1438-1444,7.DOI:10.3969/j.issn.1000-4718.2011.07.036
G蛋白偶联受体激酶在细胞迁移和细胞信号转导中的作用
Role of G-protein-coupled receptor kinases in cell migration and signal transduction
摘要
Abstract
G-protein-coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases. The investigators pay much attention to the roles of GRKs in the signal transduction through G-protein-coupled receptors (GPCRs) with arrestin ever since a long time ago. Due to the physiological and pathological observations with the methods of deletion or overexpression, GRKs are considered as new drug targets. The kinases play a role in the pathogenesis of hypertension and cell migration through GPCRs and Hedgehog signaling pathways. As the development of research techniques, especially bioluminescence resonance energy transfer (BRET) and fluorescence resonance energy transfer (FRET), the special mechanism of GRKs for GPCRs is more evident. In this review, we discuss the recent achievement in the roles of GRKs signaling and the related newest research techniques.关键词
G蛋白偶联受体激酶类/受体,G蛋白偶联/信号转导Key words
G-protein-coupled receptors kinases/Receptors,G-protein-coupled/Signal transduction分类
生物科学引用本文复制引用
蔡欣,陈京,张敬美,白波..G蛋白偶联受体激酶在细胞迁移和细胞信号转导中的作用[J].中国病理生理杂志,2011,27(7):1438-1444,7.基金项目
国家自然科学基金资助项目(No.30971081 （）
No.30870932 （）
No.81070961) （）
山东省自然科学基金资助项目(No.Y2007D01 （）
No.ZR2009DZ004) （）
