安徽医科大学学报2011，Vol.46Issue(7)：686-689,4.
CHOP方案对68例外周T细胞淋巴瘤-非特指型患者的疗效及其影响因素分析
Effects and influencing factors of CHOP regimen on 68 cases of peripheral T-cell lymphoma-unspecified
吴狄 1顾康生1
作者信息
- 1. 安徽医科大学第一附属医院肿瘤内科,合肥,230022
- 折叠
摘要
Abstract
Objective To analyze the short-term efficacy and long-term survival of CHOP regimen on peripheral Tcell lymphoma-unspecified ( PTCL-U ) patients and explore the possible influencing factors. Methods Clinical materials of 68 PTCL-U patients were analyzed. That survival rate and the influencing factors of patients treated with chemotherapy and chemotherapy combined with radiotherapy were analyzed by Kaplan-Meier analysis. The possible influencing factors of survival were analyzed by single factor analysis and the Cox proportional hazards regression model. Results Complete remission ( CR ) rate of 68 PTCL-U patients was 28％. 5-year survival rate was 25. 63％ . The survival of patients had been improved for initial treatment with CR. Chemotherapy combined with radiotherapy in long-term survival rate was significantly superior to chemotherapy alone ( P ＜ 0. 05 ). PS score before treatment. curative effect and bone marrow invasion were the independent factors which affected quality of life.Conclusion CHOP regimen has higher curative effect and lower long-term survival rate in PTCL-U patients. Initial treatment with CR and chemotherapy combined with radiotherapy can improve patient survival.关键词
淋巴瘤,T细胞,外周/抗肿瘤联合化疗方案/综合疗法Key words
lymphoma,T-cell,peripheral/antineoplastic combined chemotherapy protocols/combined modality therapy分类
医药卫生引用本文复制引用
吴狄,顾康生..CHOP方案对68例外周T细胞淋巴瘤-非特指型患者的疗效及其影响因素分析[J].安徽医科大学学报,2011,46(7):686-689,4.
