中国组织工程研究与临床康复2011，Vol.15Issue(21)：3887-3890,4.DOI:10.3969/j.issn.1673-8225.2011.21.020
壳聚糖/聚己内酯共混膜的制备及性能
Preparation and properties of chitosan/poly (ε-caprolactone) blend films
摘要
Abstract
BACKGROUND: Chitosan/poly(ε-caprolactone) (Chitosan/PCL) blend has a perspective in biomaterials. However, it is still unknown that the correlation between protein adsorption and cell activity on blends.OBJECTIVE: To investigation the correlation between protein adsorption behaviors and cell activities on chitosan/PCL blend films METHODS: Chitosan/PCL films with different mass ratios were prepared by spin coating with chitosan/PCL mixture solution. Atomic force microscopy (AFM), drop shape analyzer (DSA), quartz crystal microbalance (QCM) and MTT method were used to analyze the surface morphology, hydrophilicity, protein adsorption and cell metabolic activity of films. RESULTS AND CONCLUSION: The topography, hydrophilicity, protein adsorption and cell metabolic activity of films are largely related to the mass ratio of chitosan and PCL. The cell metabolic activity observed on hydrophobic PCL films is superior and cell adhesion level on hydrophilic chitosan films is excellent.关键词
壳聚糖/聚己内酯/共混膜/蛋白质黏附/牛血清白蛋白/细胞活性分类
医药卫生引用本文复制引用
闵翔,唐敏健,焦延鹏,周长忍..壳聚糖/聚己内酯共混膜的制备及性能[J].中国组织工程研究与临床康复,2011,15(21):3887-3890,4.基金项目
the National Natural Science Foundation of China,No.50903039 （）
Doctoral Program of Higher Education Research Funding,No.20094401120006 （）
the Natural Science Foundation of Guangdong Province,No.9451063201002459 （）
Basic Research Funding for Key Colleges,No.21609205 （）
