中国组织工程研究与临床康复2011，Vol.15Issue(19)：3590-3593,4.DOI:10.3969/j.issn.1673-8225.2011.19.041
诱导性多能干细胞诱导效率和方法的研究进展
Research progress on induced efficiency and methods of induced pluripotent stem cells
摘要
Abstract
BACKGROUND: Induced pluripotent stem cells (iPS) is a type of pluripotent stem cell artificially derived from human or animal adult somatic cells which were transfected with certain pluripotency genes. At present, the researches on induced pluripotent stem cells have made great progresses. OBJECTIVE: to review the research progress in the conversion efficiency and optimization of induction methods in iPS cells. METHODS: A computer-based online search of Medline database (http://www.ncbi.nlm.nih.gov/Pubmed) from January 2006 to July 2010 was performed with the key words of “induced pluripotent stem cells” in English. The literatures were limited to English language. totally 1 831 literatures were retrieved, 57 documents of which were involved for summarization. RESULTS AND CONCLUSION: The researches on iPS cells have a great and far-reaching impact on life science, which makes it become a hot issue in stem cell field. And some rapid progresses have been made in iPS research such as cellular reprogramming, the improvement of efficiency of induction, optimization of the induction methods, the enlargement of cell origin and differentiation of functional cells. These researches would lay a foundation for clinical cell replacement therapy of iPS.关键词
诱导性多能干细胞/重编程/效率/诱导方法/文献综述分类
基础医学引用本文复制引用
张恩欢,胡智兴,李玛琳..诱导性多能干细胞诱导效率和方法的研究进展[J].中国组织工程研究与临床康复,2011,15(19):3590-3593,4.基金项目
重大新药创制"十一五"国家科技重大专项(2008ZX09202-005),国家自然科学基金项目(30860357). （2008ZX09202-005）
