中国组织工程研究与临床康复2011，Vol.15Issue(21)：3909-3912,4.DOI:10.3969/j.issn.1673-8225.2011.21.025
采用HA130型树脂灌流器血液灌流对维持性血液透析患者微炎症的影响
Effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in maintenance hemodialysis patients
摘要
Abstract
BACKGROUND: Studies have found that the microinflammatory state exists in uremic patients undergoing maintenance hemodialysis (MHD).OBJECTIVE: To investigate the effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in MHD patients.METHODS: Sixty uremia patients undergoing maintenance hemodialysis were divided into two groups: hemoperfusion group (n=30) and MHD group (n=30). Hemoperfusion group underwent the treatment of hemoperfusion using HA130 resin hemoperfusion apparatus combined with hemodialysis. MHD group underwent the treatment of hemodialysis. The serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL–6) and tumor necrosis factor alpha (TNF-α) of all patients in the two group were detected before and after the treatment.RESULTS AND CONCLUSION: In the hemoperfusion group, the serum levels of hs-CRP, IL-6 and TNF-α were lower after treatment than those before treatment, and the difference was significant (P ＜ 0.05); In the MHD group, the serum levels of hs-CRP, IL-6 and TNF-α were higher after treatment than those before treatment, and the difference was not significant (P ＞ 0.05).The results indicate that hemoperfusion using HA130 resin hemoperfusion apparatus can reduce the serum levels of hs-CRP, IL-6 and TNF-α and control the microinflammatory state in MHD patients.关键词
微炎症/HA130型树脂灌流器/维持性血液透析/血液灌流/高敏C-反应蛋白/白细胞介素6/肿瘤坏死因子α分类
基础医学引用本文复制引用
周西豫,宋洁,张晓东,李瑛,李辉..采用HA130型树脂灌流器血液灌流对维持性血液透析患者微炎症的影响[J].中国组织工程研究与临床康复,2011,15(21):3909-3912,4.基金项目
the Natural Science Foundation of Tianjin,No.09JCYBJC09900 （）
