山西医科大学学报2011，Vol.42Issue(6)：494-496,3.DOI:10.3969/J.ISSN.1007-6611.2011.06.014
阿仑膦酸钠对绝经后妇女骨质疏松症治疗及骨折的预防作用
Alendronate sodium in the treatment of postmenopausal osteoporosis and its preventive effect on fracture
常晓芬 1温广华2
作者信息
- 1. 广东省佛山市机关保健办公室,佛山,528000
- 2. 佛山市第一人民医院核医学科
- 折叠
摘要
Abstract
Objective To explore the effect of alendronate sodium on the postmenopausal osteoporosis and its preventive effect on fracture. Methods A total of 165 postmenopausal osteoporosis women were randomly divided into two groups:treatment group( n= 83 )and control group( n= 82 ). The patients in 2 group were both given orally calcium carbonate 600 mg every night and alfacalcidol 0.25 μg twice a day. The patients in treatment group were orally given alendronate sodium 70 mg weekly in addition. The bone mineral density ( BMD ) of lumbar and left hip was detected using dual-energy X-ray absorptiometry (DEXA )before and after treatment for 2 years.During treatment the improvement of bone pain was observed, and fracture events were recorded during follow up. Results After treatment for 2 years, BMD of lumbar vertebrae and the left hip were improved in yawing degrees. After treatment for 2 years, BMD rose by 15.7％ for lumbar vertebrae and 20.8％ for femoral neck ( both P ＜ 0.05 ). The bone mineral density in control group decreased to different extent after treatment, but there was no statistical difference ( P ＞ 0.05 ). BMD was statistically different after treatment between two groups ( P ＜ 0.01 ). The rates of pain relief were 80.7％ in treatment group and 24.4％ in control group after treatment four weeks( P =0.021 ),and the rates were 89.2％ in treatment group and 30.5％ in control group after treatment for three months( P=0.029 ). Fracture occurred in one case in treatment group and 7 cases in control group. The incidence of fracture was statistically different between two groups ( P ＜ 0.05 ). The adverse reactions showed no significant difference between two groups. Conclusion Allen phosphonate sodium has a good efficacy for postmenopausal osteoporosis,and can prevent the fracture.关键词
阿仑膦酸钠/骨质疏松/骨折/绝经后Key words
allen phosphonate sodium/ osteoporosis/ fracture/ postmenopausal分类
医药卫生引用本文复制引用
常晓芬,温广华..阿仑膦酸钠对绝经后妇女骨质疏松症治疗及骨折的预防作用[J].山西医科大学学报,2011,42(6):494-496,3.
