法医学杂志2011，Vol.27Issue(2)：117-119,124,4.DOI:10.3969/j.issn.1004-5619.2011.02.009
犬组织中艾司唑仑在甲醛溶液中的稳定性
Stability of Estazolam in Dog Tissues Preserved in Formaldehyde Solution
摘要
Abstract
Objective To investigate the stability of estazolam in biological samples preserved in formaldehyde solution. Methods The dog was given intragastric administration of estazolam with a dose of 37.6 mg/kg and killed 2h later. Heart, liver, kidney and brain of the dog were cut up into 1 g and preserved in 4％formaldehyde solution respectively. The content of estazolam in biological samples and formaldehyde solution were analyzed by HPLC at different times. Results The content of estazolam in heart, liver, kidney and brain or in formaldehyde solution reduced gradually followed with the extention of preservation time.At the 63 th day, estazolam content in four tissues were 0.8％, 1.7％, 1.0％ and 2.2％ of the original content respectively. Conclusion Estazolam in tissues can diffuse into formaldehyde solution and decomposed quickly, so biological samples contained estazolam should not be preserved in formaldehyde solution.关键词
法医毒理学/艾司唑仑/甲醛/稳定性/犬Key words
forensic toxicology/ estazolam/ formaldehyde/ stability/ dogs分类
社会科学引用本文复制引用
原九喜,王玉瑾,贠克明..犬组织中艾司唑仑在甲醛溶液中的稳定性[J].法医学杂志,2011,27(2):117-119,124,4.基金项目
山西省自然科学基金资助项目(2007011105) （2007011105）
"十一五"国家科技支撑计划项目(2007BAK26B05) （2007BAK26B05）
