中国当代儿科杂志2011，Vol.13Issue(6)：466-470,5.
儿童急性淋巴细胞白血病T细胞受体重排删除环与严重感染相关性研究
Correlation between blood T-cell receptor rearrangement excision circles levels and severe infection in children with acute lymphoblastic leukemia
摘要
Abstract
Objective This study quantitatively examined signal joint T-cell receptor rearrangement excision circles (sjTRECs) levels in peripheral blood of children with acute lymphoblastic leukemia (ALL) at different stages in order to evaluate the role of sjTRECs in predicting severe infection postchemotherapy. Methods sjTRECs levels in peripheral blood were measured by fluorescent quantitation-polymerase chain reaction in 30 children with newly diagnosed ALL, 36 children with ALL who accepted chemotherapy but were not infected, 30 children with ALL who had severe infection after chemotherapy, and 50 normal children. Results Blood sjTRECs levels in the normal group (394 ±270 copies/103 MNC)were significantly higher than those in the other three groups ( P ＜ 0.05 ). Blood sjTRECs levels in the chemotherapy group without infection (96 ± 78 copies/103 MNC ) were significantly lower than those in the newly diagnosed ALL group (210 ±219 copies/103 M NC ) (P ＜ 0.05 ). The chemotherapy group with severe infection showed the lowest blood sjTRECs levels (48 ±40 copies/103 MNC) in the four groups. Conclusions The measurement of blood sjTRECs levels might be helpful for predicting the occurrence of severe infection postchemotherapy in children with ALL.关键词
T细胞受体重排删除环/急性淋巴细胞性白血病/感染/儿童Key words
T cell receptor rearrangement excision circle/ Acute lymphoblastic leukemia/ Infection/ Child分类
医药卫生引用本文复制引用
罗成娟,沈树红,周敏,顾龙君,江华,陈静,戴家乐,沈小钰,薛惠良,汤静燕,罗长缨,潘慈..儿童急性淋巴细胞白血病T细胞受体重排删除环与严重感染相关性研究[J].中国当代儿科杂志,2011,13(6):466-470,5.基金项目
上海市卫生局课题(项目编号:2007142). （项目编号:2007142）
